Chinese scientists get male rats to give BIRTH by conjoining them with females and transplanting a uterus in 'vile Frankenscience' study
Title : Chinese scientists get male rats to give BIRTH by conjoining them with females and transplanting a uterus in 'vile Frankenscience' study
Link : Chinese scientists get male rats to give BIRTH by conjoining them with females and transplanting a uterus in 'vile Frankenscience' study
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- Researchers from China joined together a male and female rat to 'share blood'
- They then grafted a uterus into the male and made both of the rats pregnant
- They did so by implanting a developing embryo from another female Lewis rat
- This allowed them to grow the embryo to term within the male grafted uterus
- Of 280 embryos implanted in 46 male rats njustn 10 sunbnrvived to be born as pups
- Peta described the study as 'vile' and a form of Frankenscience on sensitive ratsA male rat in China has given birth by Caesarean section after a 'vile' experiment that involved joining it to a female rat and transplanting a uterus.
Scientists from the Naval Medical University in Shanghai said the experiment may have 'a profound impact on reproductive biology.'
They did not spell out the implications for humans but it comes after studies exploring the possibility of transplanting a uterus into transgender women The team joined a male and female rat together by attaching their skin and sharing their blood, then transplanting a uterus into the male and implanting embryos into both male and female rats.The embryos were allowed to develop to term, that is 21.5 days, with ten successful pups out of 27 'normal' embryos in the male delivered by Caesarean section.
Those went on to live into adulthood and were able to reproduce, suffering no wider ill effects to heart, lung or liver, the team explained.
The scientists said: 'A mammalian animal model of male pregnancy was constructed by us.' However, PETA's Senior Science Policy Advisor, Emily McIvor, called the study 'frankenscience' and 'vile'.
For the study they joined a male and female rat together by attaching their skin and sharing blood between the two halves of the new pairing, then transplanting a uterus into the male half and implanting embryos into both male and female rats
For the study they joined a male and female rat together by attaching their skin and sharing blood between the two halves of the new pairing, then transplanting a uterus into the male half and implanting embryos into both male and female rats
The scientists said they were inspired to see if an embryo could survive in a 'male uterus' by male seahorses who give birth.
Male pregnancy is an incredibly rare phenomenon in nature - so rare that syngnathidae, a family of fish which includes seahorses, pipefishes, and seadragons, is the only known species where males carry offspring in pregnancy.
The study builds on earlier experiments where mouse embryos were implanted into other parts of the male body - not a uterus - but they only develop for a short time.
So they designed a 'rat model' that removed these constraints, effectively stitching a male and female rat together to create a single conjoined entity.
But Ms McIvor told MailOnline: 'Surgically joining two sensitive rats – who endured mutilation and weeks of prolonged suffering – is unethical and in the realm of Frankenscience.'
'Rats have nervous systems just like those of humans,' she said, adding that 'they feel pain, fear, loneliness, and joy, just as humans do.'
The team used inbred Lewis rats, which have a 21 to 23 day gestation, with groups of female rats selected either for their uterus or to develop the initial embryo.
They transplanted the uterus from a female into the male rat, who had been previously castrated.
The team implanted embryos into the newly implanted uterus, as well as the native uterus of the female rat that was still joined to the male.
This allowed them to observe embryonic development in the grafted uterus of the male under pregnant blood exposure.
Implanting embryos in the uterus of the attached female rat worked as a test and also so the ones in the male could develop under the shared 'pregnancy blood'.
In total they had 46 pairs of rats conjoined together with both sides made pregnant, and a total of 562 embryos were transferred to female halves and 280 to the males.
'We found that 169 embryos had developed normally in the native uteruses of the females, whereas only 27 had developed normally in male rats,' the team, led by Rongjia Zhang, said.
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749 sharesEffectively by implanting the embryo in the female half of the pairing as well as the male, it meant their newly shared blood was under female pregnant conditions.
'Finally, we performed caesarean section if the male was pregnant,' they explained.
While performing caesarean section on the males, they found some abnormal dead foetuses - a phenomenon not observed in those born to the attached female.
There were a number of conditions found within the hundreds of embryos implanted within the 46 pairs of rats, as well as health issues within the rat pairs themselves
They castrated the male and blocked the female vagina so that both sets of rats gave birth through Caesarean section
'These dead foetuses differed from normal foetuses in terms of morphology and colour; they were accompanied by atrophied or swollen placentas,' the team said.
There were also surviving foetuses, some lasting just two hours and others more than a day, according to the researchers, who say that the body weight after two hours wasn't significantly different to those born of the female.
The ten successful pups that were born of the male rat developed into adulthood and were 'functionally reproductive, the team added.
These pups also had no obvious abnormalities in the heart, lung, liver, kidney, brain, testis, ovary or uterus, based on a histological examination.
Some of the foetuses survived to term, others were reabsorbed into the uterus, those developing in the female uterus were much more successful, the team found
'To our knowledge, pregnancy has never been reported in male mammalian animals,' the authors wrote in their paper.
'In this study, we constructed a rat model of pregnancy in the male and found that transplanted embryos were able to develop to adulthood in the grafted uteruses of males [conjoined to a female] during exposure to the blood of pregnant female.
'The success rate of the entire experiment was very low, but 10 pups were successfully delivered from males by caesarean section.'
However, to make it possible for a male with an implanted uterus to successfully develop and give birth to pups, they had to expose both the uterus and male to the blood and body of a pregnant female rat attached by their skin.
They designed a 'rat model' that removed these constraints, effectively stitching a male and female rat together to create a single conjoined entity
Peta's Ms McIvor added: 'In this vile study, after being castrated and forcibly conjoined to a female rat, male rats were cut open and implanted with a uterus and embryos were inserted in them – all to establish if they could 'successfully' produce young.
'The main result: "abnormal" dead foetuses,' she added.
'These shocking experiments are driven solely by curiosity and do nothing to further our understanding of the human reproductive system.
'Animals deserve to be respected and left in peace, not bred in laboratories, experimented on, and treated like disposable objects.'
The findings have been published in the biology pre-print server bioRxiv.org.
Chinese scientists get male rats to give BIRTH by conjoining them with females and transplanting a uterus in 'vile Frankenscience' study
Chinese scientists get male rats to give BIRTH by conjoining them with females and transplanting a uterus in 'vile Frankenscience' study
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